Somatic Mutation Rate of the APC Gene
نویسندگان
چکیده
منابع مشابه
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.
We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients. In addition to loss of heterozygosity (LOH) at the APC locus in 30 tumors, 43 other somatic mutations were detected. Twenty-one of them were point mutations; 16 nonsense and two missense mutatio...
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The mutation rate (mu) is a key biological feature of somatic cells that determines risk for malignant transformation, and it has been exceedingly difficult to measure in human cells. For this purpose, a potential sentinel is the X-linked PIG-A gene, because its inactivation causes lack of glycosylphosphatidylinositol-linked membrane proteins. We previously found that the frequency (f) of PIG-A...
متن کاملThe Measurement of Gene Mutation Rate
TABLE OF CONTENTS TEE PROBLEM The failure of attempts to produce gene variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The need for a means of measuring mutation rate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Lethals as a practicable index of mutation rate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . L Temperature as ...
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A study was undertaken in Drosophila of the mutagenic properties of representatives of the various carcinogenic chemical series: alkylating agents, nitroso compounds, hydro carbons, aromatic amines, and urethan. Mutations arising from direct intramolecular DNA damage, such as point mutations and chromosome breaks leading to viable rear rangements, occurred only with the alkylating agents and th...
متن کاملa patient with desmoid tumors and familial fap having frame shift mutation of the apc gene
desmoids tumors, characterized by monoclonal proliferation of myofibroblasts, could occur in 5-10% of patients with familial adenomatous polyposis (fap) as an extra-colonic manifestation of the disease. fap can develop when there is a germ-line mutation in the adenomatous polyposis coli gene. although mild or attenuated fap may follow mutations in 5΄ extreme of the gene, it is more likely that ...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Oncology
سال: 2001
ISSN: 1465-3621
DOI: 10.1093/jjco/hye042